Wilhelm; Klaus P., Elsner; Peter, Berardesca; Enzo, Maibach; Howard I.:  Bioengineering of the Skin: Skin Surface Imaging and Analysis  Through continuous research and development of modern instrumentation, it is now possible to visualize minute structures of the skin surface not visible to the human eye. Bioengineering of the Skin: Skin Surface Imaging and Analysis, written by an internationally based group of scientists, addresses engineering techniques for visualizing and analyzing skin surface images and profiles. This skin bioengineering reference offers comprehensive information about the technology of instruments in this field and the art of applying them in experimental studies. It explains what the instruments measure and why and when they should be used in skin research and product testing  Audience:  Cosmetic chemists and researchers  Dermatologists  Biomedical engineers  Skin pharmacologists  Radiologists  Biologists involved with skin and hair  Pharmaceutical researchers  University and medical school libraries/bookstores    Contents: Anatomy of the Skin Surface. HARDWARE AND MEASURING PRINCIPLES. A: Image Analysis. The Laser-Scanning Confocal Microscope. D-Squame(r) Adhesive Discs. Kawai's Method/Nitrocellulose Replica Method. The SkinVisiometer-A Photometric Device for the Measurement of Skin Surface. Scanning Electron Microscopy. Analysis of Pigmentation of Human Skin (UV-Light Images). Polarized Light Photography of Human Skin. Use of Sebutape Assessed by Image Analysis to Measure Sebaceous Gland Activity. Image Analysis of Cyanoacrylate Follicular Biopsies. B: Profilometry. Laser Profilometry. Characterization of the Skin Surface by ISO-Parameters for Microtopography. GENERAL ASPECTS. Filter Mechanisms in the Description of Surface Topography. Tribology and the Skin Surface. Size and Shape of Corneocytes: Variation with Anatomic Site and Age. Comparison of Image Analysis with Profilometry. Comparative Studies of Scanning Electron Microscopy and Transmission Electron Microscopy. CLINICAL AND EXPERIMENTAL PPLICATIONS. Morphometry in Clinical Dermatology. Measurement of Human Hair Growth. Atopic Dermatitis and Other Skin Diseases. Skin Irritation: Objective Characterization in a Clinical Perspective. Dry Skin (Xerosis): Clinical Scoring and Instrumental Characterization. Differentiation between Nevocellular Nevi and Malignant Melanoma by Skin Roughness Parameters. PRODUCT TESTING. Effects of Detergents. Evaluation of Moisturizers. Assessment of Visual Signs of Skin Aging. Skin Atrophy Caused by Corticosteroids.  Features: Provides background information about the anatomy of the skin surface and gives detailed information on instrumentation  Clearly describes instruments necessary for quantitative testing of effects and side effects of dermatological products and cosmetics  Covers safety and efficacy testing of cosmetics and dermatological drugs  Provides easily accessible information on the many methods presently available by providing basics, pitfalls, strengths/weaknesses, and specific applications of the various methods  Includes more than 200 photographs and illustrations showing techniques and analysis methods Contains 12 pages of full-color photographs    Publication Pricing: ISBN: 0849383757, No of pages: 384 Price: $139.95, Publication Date: 12/03/96

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